SCIENCE

We have identified a preclinical lead compound from Aria’s chemical library.

 

• The mechanism of action (MOA) of ARN2966 is currently under study and appears to be novel. ARN2966 reduces expression of APP with resultant lower production of Aβ. This potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development.

 

• ARN2966 is a potent post-transcriptional modulator of APP expression in transfected CHO cells that produce amyloid precursor protein (APP).

 

• ARN2966 is easily synthesized, bioavailable, and shows BBB penetration following oral and intravenous administration to mice.

 

• Proof of Concept of ARN2966’s in vivo efficacy and tolerability has been established in AD transgenic mice. ARN2966 treatment improves the memory of mice and reduces A load in the brain.

 

• ARN2966 and its analogues are prepared by a simple chemistry from readily available inexpensive starting materials.  Scale-up and cost of goods are not expected to be barriers to development.

 

• ARN2955, a newly synthesized analogue of ARN2966 has been shown to have equal potency in vitro and superior BBB penetration in mice.

 

CONTACT

 

Aria Neurosciences, Inc.

295 Washington Ave, Suite 4N

Hamden, CT 06518

Tel:(203) 815-5782

www.arianeurosciences.com

Alzheimer's Disease

Copyright © 2013 Aria Neurosciences, Inc.

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